Young Blood

Juan Ponce de Leon famously searched for the Fountain of Youth in Florida. According to recent research, perhaps he would have had more success if he had been imitating Nosferatu and consuming blood from the young.

According to experiments on mice by teams of researchers at Harvard, Stanford, UC Berkeley, UC San Francisco, and elsewhere, young blood rejuvenates tissues and organs including muscles, liver, heart, and brain, when injected into old mice.

In one study the researchers surgically connected the circulation systems of each old mouse with a young mouse, thus allowing the young blood to flow into the old mouse. Their results showed a substantial reversal of nervous system aging in the older mice. They concluded:

“Our data indicate that exposure of aged mice to young blood late in life is capable of rejuvenating synaptic plasticity and improving cognitive function.”

Results with the mice look so promising as a potential treatment for Alzheimer’s, that a biomedical startup called Alkahest has started running a small clinical trial that involves injecting human blood plasma from young people into dementia patient volunteers. Half of the recipients will receive 4 weekly injections of young blood while the other half will act as a control group and receive injections of a placebo (saline solution). They will be monitored for a year and results are expected to be available in October 2015.

In related work, researchers are trying to identify the factor(s) in young blood that are responsible for its effect on aging. A paper from Lee Rubin et al of Harvard has identified and tested a protein called growth differentiating factor 11 (GDF-11) that has shown unexpected ability to reverse the effects of aging on the brains of mice.

Another Harvard researcher, Amy Wagers, leads a team that has been utilizing GDF-11 for several years to improve muscle function in mice. In one study Wagers has found that increased GDF11 levels in aged mice improved muscle structure and function, providing increased strength and endurance.

Perhaps the next time I  babysit my grandchildren I should ask to be paid in blood.